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The bioactivation of tramadol by CYP2D6 is a vital source of variability resulting from drug interaction. The analgesic efficacy of tramadol might be considerably minimized by CYP2D6 inhibitors, like some SSRIs or terbinafine [114, 115].Consider prescribing naloxone concomitantly for individuals that are at enhanced risk of opiate overdosage or who

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